Platelet aggregation and chlorpromazine therapy.

Optic atrophy during chlorpromazine therapy.

Chlorpromazine hydrochloride, a synthetic phenothiazine, has been widely employed in psychiatric illnesses, and an extensive literature exists on its side-effects; many reports describe ocular changes, including an oculo-dermal melanosis with deposition of pigment in the retina (Feldman and Frierson, I964; Zelickson and Zeller, I964; Cairns, Capoore, and Gregory, I965; Brit. med. J., I967), dep...

Platelet Phagocytosis and Aggregation

The addition of latex particles to native (no anticoagulant) or citrated human platelet-rich plasma (PRP), or to a once-washed platelet suspension causes platelet aggregation. This aggregation is associated with phagocytosis of the latex particles by the platelets and appears to be due to release of adenosine diphosphate (ADP) from the platelets. Adenosine and adenosine monophosphate, which are...

Platelet lipid composition and platelet aggregation

Abnormal plasma lipoproteins in patients with liver disease are associated with an increase in erythrocyte cholesterol concentration and a raised erythrocyte cholesteroVphosphoEpid molar ratio. We hypothesized that their platelets would also have an increased cholesteroVphospholipid ratio and that this might affect aggregation in vitro. Platelet aggregation by adrenaline and ADP was measured in...

Platelet aggregation, platelet serotonin and pancreatitis.

Reduced platelet hyper-reactivity and platelet-leukocyte aggregation after periodontal therapy

BACKGROUND Platelets from untreated periodontitis patients are hyper-reactive and form more platelet-leukocyte complexes compared to cells from individuals without periodontitis. It is not known whether the improvement of the periodontal condition achievable by therapy has beneficial effects on the platelet function. We aimed to assess the effects of periodontal therapy on platelet reactivity. ...